DEVELOPMENT OF NILOTINIB LOADED SOLID LIPID NANOPARTICLES AND OPTIMIZATION BY CENTRAL COMPOSITE DESIGN APPROACH
نویسندگان
چکیده
Objective: In current research, solid lipid nanoparticles (SLN) are formulated for the anticancer drug, nilotinib, to conquer drawbacks associated with drug including low bioavailability and solubility. Methods: The formulation comprised of tripalmitin (lipid), poloxamer 188(surfactant) glyceryl palmitostearate (cosurfactant) by solvent evaporation technique. process variables SLN were optimized experimental design-Central composite design (CCD). effect ratio (A), concentration Poloxamer 188 (B) palmitostearate(C), on particle size (Y1) encapsulation efficiency (Y2) evaluated. Three batches (F1-F3) Nilotinib SLNs desirability approach Results: mean all formulations ranged between 187–198 nm, PDI 0. 291-0.652 zeta potential between-21.8 to-24.7 mV indicating wide range distribution stabiliity formulations. total 85 86 %. SEM analysis revealed spherical shape individual particles PXRD results indicate amorphization in formulation. release was continued 24 h, indicative controlled delivery. Conclusion: From above it is concluded that solubility nilotinib enhanced.
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2022
ISSN: ['0975-7058']
DOI: https://doi.org/10.22159/ijap.2022v14i2.43943